What non-neurogenic factor can lead to detrusor atony?

Detrusor atony refers to the decreased tone or contraction of the detrusor muscle, which is responsible for bladder contraction during urination. One significant non-neurogenic factor that can lead to detrusor atony is overdistension of the bladder.

When the bladder is chronically overdistended, it can disrupt normal muscle function. This occurs because prolonged stretching of the detrusor muscle can damage the muscle fibers and impair their ability to contract effectively. Additionally, overdistension can affect cellular connections, such as tight junctions between muscle cells, leading to further dysfunction. This may result in the muscles being unable to contract adequately, causing urinary retention and detrusor atony.

Conversely, the other choices involve factors related to neurological conditions, infections, or obstructive processes that do not directly pertain to the mechanical aspect of detrusor muscle function like overdistension does.